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科学研究

研究成果概况

信息来源: 发布日期:2021-01-04

质谱成像与代谢组学国家民委重点实验室骨干人员近三年,围绕质谱成像技术和代谢组学的关键科学问题和前沿技术难题,聚焦分析新技术、新方法的研究,并推进相关技术与方法的应用研究,取得了良好的研究进展和一些创新成果。以中央民族大学为第一单位发表论文36篇,其中SCI论文29篇,其中一区期刊14篇(A+类,含11Top类)、二区8篇,包括Anal. Chem.Acta Pharm. Sin. BChem. Commun.Ind. Crop. Prod.等权威或重要学术期刊;申请专利6项,授权3项。相关成果在质谱成像、空间分辨代谢组学和分子原位表征等领域处于国际先进水平。

序号

作者

论文题目

期刊、年度

卷(期)及页

期刊信息

1

Zhonghua Wang1,   Wenqing Fu1, Meiling Huo, Bingshu He, Yaqi Liu, Lu Tian, Wanfang   Li, Zhi Zhou, Baili Wang, Jianzhen Xia, Yanhua Chen, Jinfeng Wei, Zeper   Abliz*

Spatial-resolved   metabolomics reveals tissue-specific metabolic reprogramming in diabetic   nephropathy by using mass spectrometry imaging

Acta Pharmaceutica   Sinica B

2021, 11(11):

3665-3677

SCI一区(A+类)

并入选中国科技期刊卓越行动计划领军期刊

2

Zhi Zhou, Bing Xie,   Bingshu He, Chen Zhang, Lulu Chen, Zhonghua Wang, Yanhua Chen, Zeper Abliz*

Multidimensional   molecular differences between artificial cultivated and wild Artemisia   rupestris L. based on metabolomics–transcriptomics integration strategy

Industrial Crops &   Products

2021, 170: 113732

SCI一区(A+类),

农林科学Top

3

Haiqiang Liu, Manman Han, Jinming Li, Liang Qin, Lulu Chen,   Qichen Hao, Dongxu Jiang, Difan Chen, Yuanyuan Ji, Hang Han, Chunlin Long, Yijun   Zhou, Jinchao Feng, and Xiaodong Wang*

A Caffeic Acid Matrix Improves In Situ Detection and Imaging of   Proteins with High Molecular Weight Close to 200,000 Da in Tissues by   Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Imaging

Analytical Chemistry

2021, 93:

11920-11928

SCI一区(A+类)

化学Top

4

Zhang Ruifei, Ji Yuanyuan, Taylan Morcol, Lin Fengke, Gu   Ronghui, Edward Kennelly*, Long Chunlin*

UPLC-QTof-MS chemical profiling and characterization of   antiproliferative and anti-inflammatory compounds from seven Hypericum   species in China

Industrial Crops & Products.

2021, 171: 11415.

SCI 一区(A+类)

农林科学Top

5

Ji Yuanyuan, Yang Junyi, Zhang Ruifei, Chen Qingyu, Xu Rui, Wei   Xuejin, Chen Xiaohang, Chen Shanxi, Guo Fanding, Edward Kennelly, Long   Chunlin*

Chemical characterization, neuroprotective, antimicrobial and   enzyme inhibitory activities of Hypericum volatile oils.

Industrial Crops & Products.

2021, 171: 113991.

SCI 一区(A+类)

农林科学Top

6

Luo Binsheng, Ertan Kastrat, Taylan Morcol, Haiping Cheng,   Edward Kennelly*, Long Chunlin*

Gaultheria longibracteolata, an alternative   source of wintergreen oil

Food Chemistry.

2021, 342: 128244.

SCI 一区(A+类)

农林科学Top类)

7

Meng Xia, Lijun Duan, Binan Lu, Yuzhou Pang, Zongran Pang

LncRNA AFAP1-AS1/miR-27b-3p/VEGF-C axis modulates stemness   characteristics in cervical cancer cells.

Chinese Medical Journal,

2021, 134(17): 2091-2101.

中国科技期刊卓越行动计划领军期刊

A+类)

8

Zhonghua Wang, Bingshu He, Yaqi Liu, Meiling Huo, Wenqing Fu,   Chunyan Yang, Jinfeng Wei, Zeper Abliz*

In situ metabolomics in nephrotoxicity of aristolochic acids   based on air flow-assisted desorption electrospray ionization mass   spectrometry imaging.

Acta Pharmaceutica Sinica B

2020, 10(6): 1083-1093.

SCI一区(A+类),

并入选中国科技期刊卓越行动计划领军期刊

9

Fengke Lin, Fei Cai,   Binsheng Luo, Ronghui Gu, Selena Ahmed, Chunlin Long*

Variation of   microbiological and biochemical profiles of Laowo dry-cured ham, an   indigenous fermented food, during ripening by GC-TOF-MS and UPLC-QTOF-MS

Journal of   Agricultural and Food Chemistry

2020, 68(33):   8925-8935

SCI一区(A+类),

农林科学Top

10

Binsheng Luo, Ertan   Kastrat, Taylan Morcol, Haiping Cheng, Edward Kennelly*, Chunlin Long*

Gaultheria   longibracteolata, an alternative source of wintergreen oil Gaultheria   longibracteolata, an alternative source of wintergreen oil

Food Chemistry

2020, 342: 128244

SCI一区(A+类),

农林科学Top

11

Yaqin Liu, Lulu Chen,   Liang Qin, Manman Han, Jinming Li, Feixian Luo, Kun Xue, Jinchao Feng, Yijun   Zhou, Xiaodong Wang*

Enhanced in situ   detection and imaging of lipids in biological tissues by using   2,3-dicyanohydroquinone as a novel matrix for positive-ion MALDI-MS Imaging

Chemical   Communications

2019, 55(83):   12559-12562.

SCI一区(A+类),

化学类

12

Huixin He, Liang Qin,   Yawen Zhang, Manman Han, Jinming Li, Yaqin Liu, Kaidi Qiu, Xiaoyan Dai,   Yanyan Li, Maomao Zeng, Huihong Guo, Yijun Zhou, Xiaodong Wang*

3,4-Dimethoxycinnamic   acid as a novel matrix for enhanced in situ detection and imaging of   low-molecular-weight compounds in biological tissues by MALDI-MSI

Analytical Chemistry

2019, 91(4):

2634-2643

SCI 一区(A+类)

13

Ronghui Gu, Taylan Morcol, Bo   Liu, Minjie Shi, Edward J Kennelly.*, Chunlin Long*

GC-MS, UPLC-QTOF-MS,   and bioactivity characterization of Acer truncatum seeds

Industrial Crops &   Products

2019, 138: 111480.

SCI一区(A+类),

农林科学Top

14

Ronghui Gu, Levi Rybalov, Adam   Negrin, Taylan Morcol, Long Weiwen, Amanda K. Myers, Giorgis Isaac, Jimmy   Yuk, Edward J. Kennelly*, Chunlin Long*

Metabolic profiling of   different parts of Acer truncatum from the Mongolian Plateau using   UPLC-QTOF-MS with comparative bioactivity assays

Journal of   Agricultural and Food Chemistry

2019, 67(5): 1585-1597

SCI一区A+类),

农林科学Top

15

Yiyang Shi1,   Hao Hu1, Qichen Hao1, Ran Wu,

Lei Wang, Liang Qin,   Wei Gu, Haiqiang Liu, Dongxu Jiang, Liya Hong, Yijun Zhou, Xiangyi Liu,   Jinchao Feng, Kun Xue*,

Xiaodong Wang*.

Michler's ethylketone   as a novel negative-ion matrix for the enhancement of lipid MALDI tissue   imaging

Chemical Communications  

2022, 58(5): 633-636

SCI二区(A类)

16

Lamei Zheng, Wuyun Wu,   Yunfei Gao, Yingxin Wu, Yixiao Xu, Genfa Zhang, Fei Gao*, Yijun Zhou*

Integrated   transcriptome, small RNA and degradome analysis provide insights into the   transcriptional regulatory networks underlying cold acclimation in jojoba

Scientia Horticulturae

2022, 299: 111050

SCI 二区

A类)

17

Meiling Huo, Zhonghua   Wang*, Wenqing Fu, Lu Tian, Wanfang Li, ZhiZhou, Yanhua Chen, Jinfeng Wei,   Zeper Abliz*

Spatially resolved   metabolomics based on air-flowassisted desorption electrospray   ionization-mass spectrometry imaging reveals region specific metabolic   alterations in diabetic encephalopathy

Journal of Proteome   Research.

2021, 20: 3567-3579

SCI 二区

A类)

18

Ran Wu1, Liang Qin1,   Lulu Chen1, Rui Ma, Difan Chen, Haiqiang Liu, Hualei Xu, Hua Guo, Yijun Zhou,   Xiaodong Wang*

Copper adhesive tape   attached to the reverse side of a non-conductive glass slide to achieve   protein MALDI-imaging in FFPE-tissue sections

Chemical   Communications

2021, 57: 10707-1071

SCI二区(A类)

19

Xu Li, Wang Yizhou, Ji   Yuanyuan, Li Ping, Cao Wujisiguleng, Wu Shi-biao, Edward James Kennelly, Long   Chunlin*

Nutraceutical study on   Maianthemum atropurpureum, a wild medicinal food plant in Northwest Yunnan,   China.

Frontiers in Pharmacology.

2021, 12: 710487.

SCI 二区

A类)

20

Yuying Liu1, Jinchang   Du1, Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*

Recent Progress in   Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage With   Micro/Nanoelectrodes.

Frontiers in   Chemistry.

2021, 8: 591311.

SCI 二区

A类)

21

Yinjiang Zhang,   Hongyun Wei, Lu Fan, Mingyan Fang, Xu He, Binan Lu*, Zongran Pang*

CLEC4s as Potential   Therapeutic Targets in Hepatocellular Carcinoma Microenvironment.

Frontiers in Cell and   Developmental Biology.

2021, 9: 681372.

SCI 二区

A类)

22

Ye Peng, Shifeng Chu,   Yantao Yang, Zhao Zhang, Zongran Pang*, Naihong Chen*

Neuroinflammatory In   Vitro Cell Culture Models and the Potential Applications for Neurological Disorders

Frontiers in   Pharmacology

2021, 12: 671734

SCI 二区

A类)

23

Yanliang Zhang, Liang   Qin, Jingkuan Sun, Lulu Chen, Lizhi Jia, Jinqi Zhao, Hongjun Yang, Kun Xue,   Xiaodong Wang*, Weiguo Sang**

Metabolite changes   associated with earthworms (Eisenia fetida) graphene exposure revealed by   matrix-assisted laser desorption/ionization mass spectrometry imaging

Ecotoxicology and   Environmental Safety

2020, 205: 111102

SCI 二区

A类)

24

Zhonghua Wang, Xiaoyu   Xu, Bingshu He, JinghuaGuo, Baoxin Zhao, Yanping Zhang, Zhi Zhou, Xia Zhou,   Ruiping Zhang*, Zeper Abliz*

The impact of chronic   environmental metal and benzene exposure on human urinary metabolome among   Chinese children and the elderly population.

Ecotoxicology and   Environmental Safety

2019, 169: 232–239

SCI 二区

A类)

25

Chen Zhang*, Wenbin   Zhou, Xiaoying Lei, Suqing Zhao

Nitric oxide   inhibitory terpenes and its glycosides from Ainsliaea bonatii

Fitoterapia.

2021,156, 105028

SCI 三区

B类)

26

Peijie Zhang, Jun   Jiang, Ke Zhang, Wenjing Liu, Pengfei Tu, Jun Li, Yuelin Song, Jiao Zheng*,   Li Tang

Shotgun chemome   characterization of Artemisia rupestris L. using direct infusion-MS/MS ALL

Journal of   Chromatography B.

2021, 1176: 122735.

SCI 三区

B类)

27

Mengying Wang, Yuying   Liu, Jinchang Du, Junlan Zhou, Lijiao Cao, Xianchan Li*

Cisplatin Inhibits   Neurotransmitter Release during Exocytosis from Single Chromaffin Cells   Monitored with Single Cell Amperometry.

Electroanalysis

2021. 33: 1-7

SCI 三区

B类)

28

Yinghui Bai, Dongxu Shi, Hongyu Lu, Kunbao Yang, Huanhu Zhao,   Binan Lu*, Zongran Pang*

Hypoglycemic effects of Tibetan medicine Huidouba in STZ-induced   diabetic mice and db/db mice

Chinese Herbal Medicines

2021, 13: 202-209.

中国科技期刊卓越行动计划梯队期刊

B类)

29

程硕涵, 姚兰, 杨静,雷小英, 周帜, 章宸, 张青槐, 庞宇舟, 周文斌*, 再帕尔·阿不力孜

基于LC-MS/MS联用技术的民族药飞龙掌血生物碱类化学成分分析

中华中医药杂志,

202102440, 已接收

中文核心

B类)

入选中国科技期刊卓越行动计划梯队期刊

30

谢冰,   周帜,* 章宸, 陈路路,   霍美玲, 努尔波拉提阿依达尔汗,   刘戈宇, 阿吉艾克拜尔艾萨,   王中华, 再帕尔阿不力孜

基于植物代谢组学的新疆一枝蒿产地标志物多维度研究.

分析化学,  

2020, 48(6):733-741

SCI 四区

C类)

31

齐擦毛吉,沙正悦,李鲜婵*

单一神经囊泡的电分析化学研究

分析化学,  

2019, 47: 1502-1511

SCI 四区(C类)

32

和书航1, 陈路路1, 秦亮1, 戴晓艳, 邱凯笛,   陈涤凡, 王晓东*

糖尿病肾病蛋白质组学研究进展

中国科学生命科学.  

2021, 54(4), 384-411.

核心期刊

33

王晨钰, 韩涵, 郭磊, 刘同祥*, 唐丽*

傣药方在治疗新型冠状病毒感染中作用的网络药理学和分子对接分析

中国测试.

2021, 47(09): 70-81.

核心期刊

34

和书航,   陈路路, 秦亮, 戴晓艳,   邱凯笛, 陈涤凡, 王晓东*

糖尿病肾病蛋白质组学研究进展

中国科学:   生命科学

2020, 50: 1-28

核心期刊

35

刘亚琪,王中华*,何秉淑,谢冰,霍美玲,傅文清,周帜,再帕尔·阿不力孜

基于液相色谱-质谱技术的肾脏代谢组学分析方法研究

分析测试学报,  

2020, 39(01): 108-114.

核心期刊

36

张佩杰,曹妍,张珂,宋月林,李军,唐丽*

利用HPLC–IT-TOF-MS分析新疆一枝蒿的化学成分

中国中药杂志

202045(19):   4658-4666

核心期刊